Breast cancer survival not affected by faulty BRCA genes

Breast cancer survival not affected by faulty BRCA genes

AstraZeneca said this is the third indication approved for Lynparza in the United States, where it has been used to treat almost 4,000 advanced ovarian cancer patients.

Fiona MacNeill, of the Royal Marsden NHS Foundation Trust, who was not involved in the research, said: "This study can reassure young women with breast cancer, particularly those with triple negative cancer or who are BRCA carriers, that breast conservation with radiotherapy is a safe option in the first decade after diagnosis and double mastectomy is not essential or mandatory at initial treatment. This is significant for breast cancer patients, as the identification of BRCA status, in addition to hormone receptor and HER2 status, becomes a potentially critical step in the management of their disease".

Located within Penn Medicine's Abramson Cancer Center, The Basser Research Center for BRCA focuses exclusively on BRCA1 and BRCA2.

The BRCA mutation may be most famous for its association with Angelina Jolie, who announced she carried the BRCA1 mutation in 2013 in a New York Times opinion piece.

Young women with breast cancer who carry faulty BRCA genes are no less likely to survive than those without them, researchers have found. The Prospective Outcomes in Sporadic vs Hereditary breast cancer (POSH) study recruited 2,733 young women with breast cancer between 2000 and 2008.

"The study found that there was no difference in overall survival two, five or ten years after diagnosis for women with and without a BRCA mutation", a press statement said.

The researchers tracked the women a their treatment for more than eight years.

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Having a faulty BRCA gene - either BRCA1 or BRCA2 - is known to increase a woman's risk of breast cancer.

When those results were published last June, Mark Robson, an oncologist at Memorial Sloan Kettering Cancer Center who led the multisite trial, described the treatment as "an early chapter in a woman's journey" dealing with breast cancer - one that can delay the start of chemotherapy and help preserve her quality of life.

Some women have previously chose to take preventative measures, such as pre-emptive mastectomies, when they discover they have faulty genes.

Clovis' PARP inhibitor Rubraca (rucaparib) was approved in the U.S.in late 2016 for advanced ovarian cancer patients who have received at least two prior lines of chemo and whose tumors harbor the BRCA mutation.

During the course of the study, out of the 2,733 women, there were 678 deaths, including 651 deaths from breast cancer, 18 from other cancers, and nine from other causes.

"However, our findings suggest that this surgery does not have to be immediately undertaken along with the other treatment".

"Decisions about timing of additional surgery aimed at reducing future second primary-cancer risks should take into account patient prognosis associated with the first malignancy and patient preferences", the authors write.

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